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| Didek,Daiane; Cordeiro,Maiara Mikuska; Xavier,João Lucas de Paula; Ribeiro,Paulo Roberto; Rentz,Thiago; Franco,Gilson Cesar Nobre; Kanunfre,Carla Cristine; Emilio,Henriette Rosa de Oliveira; Scomparin,Dionízia Xavier. |
| Abstract The objective of this study was to evaluate the effect of liraglutide, an analog of glucagon-like peptide-1 (GLP-1) in association with physical exercise, on the metabolic and biochemical parameters of rats induced to obesity with a cafeteria diet. Male Wistar rats, aged 21 days, were randomly divided into: Controls (CON) receiving standard feed and water ad libitum; and obese (OBESE) receiving cafeteria diet ad libitum, added to the standard diet. Groups were then subdivided into: Liraglutide animals that received subcutaneous injections of liraglutide from 80 to 90 days of life; exercised (EXE) animals submitted to swimming sessions, three days a week (15 min); and liraglutide + EXE animals that received liraglutide in association with physical... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Obesity; Liraglutide; GLP-1; Metabolic syndrome; Exercise. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132019000100305 |
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| Xavier,João Lucas P.; Scomparin,Dionizia X.; Pontes,Catherine C.; Ribeiro,Paulo Roberto; Cordeiro,Maiara M.; Marcondes,Jessica A.; Mendonça,Felipe O.; Silva,Makcine T. da; Oliveira,Fabio B. de; Franco,Gilson C.N.; Grassiolli,Sabrina. |
| In the present study we analyzed morphological and metabolic alterations in dams nursing small litters and their consequences to offspring throughout lactation. Offspring sizes were adjusted to Small Litter (SL, 3 pups/ dam) and Normal Litter (NL, 9 pups/ dam). Body weight, food intake, white adipose tissue (WAT) content, histological analysis of the pancreas, mammary gland (MG) and brown adipose tissue (BAT) as well as, plasma parameters and milk composition were measured in dams and pups on the 7th, 14th and 21st days of lactation. In general, SL-dams presented higher body weight and retroperitoneal fat content, elevated fat infiltration in BAT, reduced islets size and hyperglycemia throughout lactation in relation to NL-dams (p<0.05). Moreover, MG... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Dams; Metabolic programming; Milk; Offspring. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000100803 |
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